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Avibactam sodium
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Avibactam sodium图片
CAS NO:1192491-61-4
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议

产品介绍

化学性质

Physical AppearanceA solid
StorageStore at -20°C
M.Wt287.23
Cas No.1192491-61-4
FormulaC7H10N3NaO6S
Solubility≥28.7 mg/mL in DMSO; insoluble in EtOH; ≥48.2 mg/mL in H2O
Chemical Namesodium (1R,2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl sulfate
Canonical SMILESO=S(ON1[C@@]2(CC[C@H]([N@](C1=O)C2)C(N)=O)[H])([O-])=O.[Na+]
运输条件蓝冰运输或根据您的需求运输。
一般建议为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。

资料参考

Avibactam sodium is a β-lactamase inhibitor that does not include the β-lactam core but maintains the capacity to covalently acylate its β-lactamase targets. Avibactam sodium inhibits β-lactamases CTX-M-15 and TEM-1, with IC50 values of 5 and 8 nM, respectively. β-Lactamases are enzymes produced by bacteria, with the ability to inactivate β-lactam antibiotics by hydrolyzing the β-lactam ring. β-Lactamases are responsible for resistance to penicillins, monobactams, carbapenems, and extended-spectrum cephalosporins. Avibactam sodium combined with β-lactam antibiotics can be potentially used for the treatment of bacterial infections comprising Gram-negative organisms.

References:

1. Ehmann DE, Jahic H, Ross PL, et al. Avibactam is a covalent, reversible, non-β-lactam β-lactamase inhibitor. Proceedings of the National Academy of Sciences of the United States of America, 2012, 109(29): 11663-11668.

2. Drawz SM, Bonomo RA. Three decades of beta-lactamase inhibitors. Clinical Microbiology Reviews, 2010, 23(1): 160-201.

3. Berkhout J, Melchers MJ, van Mil AC, et al. Pharmacokinetics and penetration of ceftazidime and avibactam into epithelial lining fluid in thigh- and lung-infected mice. Antimicrobial Agents and Chemotherapy, 2015, 59(4): 2299-2304.

试验操作

Animal experiment:[3]

Animal models

A covalent, reversible, non-β-lactam β-lactamase inhibitor

Dosage form

1 ~ 128 mg/kg

Subcutaneous administration

Applications

No pharmacokinetic interaction between ceftazidime and avibactam was observed. Ceftazidime and avibactam showed linear plasma pharmacokinetics that were independent of the dose combinations used or the infection site in mice.

Note

The technical data provided above is for reference only.

References:

1. Ehmann DE, Jahic H, Ross PL, et al. Avibactam is a covalent, reversible, non-β-lactam β-lactamase inhibitor. Proceedings of the National Academy of Sciences of the United States of America, 2012, 109(29): 11663-11668.

2. Drawz SM, Bonomo RA. Three decades of beta-lactamase inhibitors. Clinical Microbiology Reviews, 2010, 23(1): 160-201.

3. Berkhout J, Melchers MJ, van Mil AC, et al. Pharmacokinetics and penetration of ceftazidime and avibactam into epithelial lining fluid in thigh- and lung-infected mice. Antimicrobial Agents and Chemotherapy, 2015, 59(4): 2299-2304.