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Benazeprilat
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Benazeprilat图片
CAS NO:86541-78-8
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
贝那普利拉是一种口服活性物质，是贝那普利的活性代谢物，贝那普利是一种具有抗高血压活性的含羧基 ACE 抑制剂。
Cas No.86541-78-8
别名苯那普利拉,CGS 14831
化学名(3S)-3-[[(1S)-1-carboxy-3-phenylpropyl]amino]-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-acetic acid
Canonical SMILESO=C1[C@@H](N([H])[C@H](C(O)=O)CCC2=CC=CC=C2)CCC3=C(N1CC(O)=O)C=CC=C3
分子式C22H24N2O5
分子量396.4
溶解度0.5mg/mL in DMSO, 0.16mg/mL in DMF
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Benazeprilat is an inhibitor of angiotensin-converting enzyme (ACE; IC50 = 0.28 nM in plasma from dog) and the active metabolite of the prodrug benazepril. [1] Benazeprilat is produced in the liver following cleavage of the ester group from benazepril. Formulations containing the prodrug benazepril have been used to treat hypertension in human and veterinary medicine.

Reference:
[1]. Toutain, P.L., and Lefèbvre, H.P. Pharmacokinetics and pharmacokinetic/pharmacodynamic relationships for angiotensin-converting enzyme inhibitors. J. Vet. Pharmacol. Ther. 27(6), 515-525 (2004).