Cefonicid(sodium salt)

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CAS NO:

61270-78-8

包装与价格：

包装	价格(元)
10mM (in 1mL DMSO)	电议
500mg	电议
1g	电议

产品介绍

化学性质

Storage	Store at -20°C
M.Wt	586.5
Cas No.	61270-78-8
Formula	C₁₈H₁₆N₆O₈S₃·2Na
Synonyms	Monocid
Solubility	≥22.95 mg/mL in DMSO; insoluble in EtOH; ≥44.5 mg/mL in H2O
Chemical Name	(6R,7R)-7-[[(2R)-2-hydroxy-2-phenylacetyl]amino]-8-oxo-3-[[[1-(sulfomethyl)-1H-tetrazol-5-yl]thio]methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, disodium salt
Canonical SMILES	O=C(N[C@H]1[C@](SCC(CSC2=NN=NN2CS([O-])(=O)=O)=C3C([O-])=O)([H])N3C1=O)[C@H](O)C4=CC=CC=C4.[Na+].[Na+]
运输条件	蓝冰运输或根据您的需求运输。
一般建议	为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。

资料参考

Cefonicid is a second-generation cephalosporin antibiotic.

Cephalosporins, the largest and most diverse family of antibiotics of the beta-lactam group, are structurally and pharmacologically related to the penicillins.

In vitro: Cefonicid was found to be similar to cefamandole in its superiority to first generation cephalosporins against several enterobacteriaceae and Haemophilus influenzae, such as beta-lactamase-producing strains. Its activity against Staphylococcus aureus was similar to that of cefoxitin and inferior to cefamandole and first generation cephalosporins. Cefonicid has excellent in-vitro activity against Neisseria gonorrhoeae, but is inactive against Pseudomonas, Serratia, Acinetobacter, and Bacteroides fragilis [1].

In vivo: The purpose of a previous study was to determine whether cefonicid caused testicular toxicity when subcutaneously administered to Sprague-Dawley male rats at doses of 50 to 1,000 mg/kg per day. The histological findings were confirmed by marked reductions in testicular sperm production rates and cauda epididymal sperm numbers. In addition, cefonicid had no treatment-related adverse effects on the sexual maturation males [2].

Clinical trial: Cefonicid was found to be comparable in efficacy with cefamandole or cefazolin in the treatment of patients with urinary tract, lower respiratory tract, and soft tissue and bone infections. It was also compared with penicillin in the treatment of uncomplicated gonorrhoea. Single doses of cefonicid appear to offer a similar degree of protection against post-surgical infection as multiple doses of other antibiotics [1].

References:
[1] Saltiel, E; Brogden, R. N. (1986). Cefonicid. A review of its antibacterial activity, pharmacological properties and therapeutic use. Drugs. 32 (3): 222–59.
[2] Manson JM, Zolna LE, Kang YJ, Johnson CM. Effects of cefonicid and other cephalosporin antibiotics on male sexual development in rats. Antimicrob Agents Chemother. 1987 Jul;31(7):991-7.