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PR-619
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PR-619图片
CAS NO:2645-32-1
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
10mM * 1mL in DMSO电议

产品名称
PR619, PR 619
产品介绍

生物活性

PR-619是一种细胞可渗透、可逆、广谱的去双基化酶抑制剂。

Targets

TargetValue
JOSD2EC50: 1.17μM
SENP6coreEC50: 2.37μM
UCH-L3EC50: 2.95μM
USP4EC50: 3.93μM
USP8EC50: 4.90μM
DEN1EC50: 4.98μM
USP20EC50: 5.10μM
USP28EC50: 6.24μM
USP7EC50: 6.86μM
USP2coreEC50: 7.20μM
USP15EC50: 8.23μM
USP5EC50: 8.61μM
USP47EC50: 8.87μM
UCH-L5EC50: 9.26μM
UCH-L1EC50: 12.8μM
PlproEC50: 14.2μM
PLA2EC50: >50μM
Calpain1EC50: >50μM
CT-LEC50: >50μM
CathepsinDEC50: >50μM
MMP13EC50: >50μM
TrypsinEC50: >50μM

化学数据

目录号A13190
作用机制Inhibitor (抑制剂)
M. Wt223.28
FormulaC7H5N5S2
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.2645-32-1
SynonymsPR619, PR 619
SMILESC1=C(C(=NC(=C1SC#N)N)N)SC#N

溶解度

In vitroDMSO42 mg/mL (188.1 mM)
WaterInsoluble
EthanolInsoluble
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM44.79 mL223.93 mL447.87 mL
0.5 mM8.96 mL44.79 mL89.57 mL
1 mM4.48 mL22.39 mL44.79 mL
5 mM0.9 mL4.48 mL8.96 mL

*The above data is based on the productmolecular weight 223.28. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.