AZD-3458 (PI3Kγ inhibitor 3) is a novel, potent, orally bioavailable and highly isoform selective PI3Kγ inhibitor with anticancer activity. It has pIC50s of 9.1, 5.1,<4.5, and 6.5 for PI3Kγ, PI3Kα, PI3Kβ, and PI3Kδ, respectively. It has ADME properties suitable for oral administration. Compound 15 was advanced into in vivo studies showing dose-dependent inhibition of LPS-induced airway neutrophilia in rats when administered orally.
理化性质和储存条件
| Molecular Weight: 433.54 Formula: C20H23N3O4S2 CAS No.: 2132961-46-5 SMILES: O=C1N([C@@H](C)C2CC2)CC3=CC(C4=C(C)N=C(NC(C)=O)S4)=CC(S(=O)(C)=O)=C31 |
---|
Storage | -20℃ for 3 years in powder form |
---|
-80℃ for 2 years in solvent |
Technical Information | AZD-3458; PI3Kγ inhibitor 3; AZD3458 |
---|