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AZD3458(PI3Kγinhibitor 3)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
AZD3458(PI3Kγinhibitor 3)图片
CAS NO:2132961-46-5
规格:≥98%
包装与价格:
包装价格(元)
10mg电议
25mg电议
50mg电议
100mg电议
250mg电议

产品介绍
AZD-3458 (PI3Kγ inhibitor 3) is a novel, potent, orally bioavailable and highly isoform selective PI3Kγ inhibitor with anticancer activity. It has pIC50s of 9.1, 5.1,<4.5, and 6.5 for PI3Kγ, PI3Kα, PI3Kβ, and PI3Kδ, respectively. It has ADME properties suitable for oral administration. Compound 15 was advanced into in vivo studies showing dose-dependent inhibition of LPS-induced airway neutrophilia in rats when administered orally.
理化性质和储存条件

Molecular Weight: 433.54
Formula: C20H23N3O4S2
CAS No.: 2132961-46-5
SMILES: O=C1N([C@@H](C)C2CC2)CC3=CC(C4=C(C)N=C(NC(C)=O)S4)=CC(S(=O)(C)=O)=C31
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Technical InformationAZD-3458; PI3Kγ inhibitor 3; AZD3458