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Costunolide
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Costunolide图片
CAS NO:553-21-9
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
5mg电议
10mg电议

产品介绍
Costunolide ((+)-Costunolide) 是一种天然存在的倍半萜内酯,具有抗氧化、抗炎、抗过敏、骨骼重塑、神经保护、促进头发生长、抗癌和抗糖尿病的特性。 Costunolide 可以诱导乳腺癌细胞的细胞周期停滞和凋亡。
Cas No.553-21-9
别名木香烃内酯; (+)-Costunolide; Costus lactone
化学名(3aS,6E,10E,11aR)-6,10-dimethyl-3-methylidene-3a,4,5,8,9,11a-hexahydrocyclodeca[b]furan-2-one
Canonical SMILESCC1=CCCC(=CC2C(CC1)C(=C)C(=O)O2)C
分子式C15H20O2
分子量232.32
溶解度≥ 35.7 mg/mL in DMSO, ≥ 45.2 mg/mL in EtOH with ultrasonic and warming
储存条件Store at -20℃, sealed storage, away from moisture and light
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述 Description: IC50 Value: 6.2 - 9.8 μg/mL(sarcoma cells viability)[3] Costunolide, a sesquiterpene lactone, exhibits anti-inflammatory and anti-oxidant properties and mediates apoptosis. in vitro: Costunolide significantly inhibited RANKL-induced BMM differentiation into osteoclasts in a dose-dependent manner without affecting cytotoxicity. Costunolide did not regulate the early signaling pathways of RANKL, including the mitogen-activated protein kinase and NF-κB pathways. However, costunolide suppressed nuclear factor of activated T-cells, cytoplasmic 1 (NFATc1) expression via inhibition of c-Fos transcriptional activity without affecting RANKL-induced c-Fos expression. The inhibitory effects ofcostunolide were rescued by overexpression of constitutively active (CA)-NFATc1 [1]. Exposure of T24 cells to costunolide was also associated with increased expression of Bax, down-regulation of Bcl-2, survivin and significant activation of caspase-3, and its downstream target PARP [2]. Both costunolide and dehydrocostus lactone inhibited cell viability dose- and time-dependently. IC50 values ranged from 6.2 μg/mL to 9.8 μg/mL. Cells treated with costunolide showed no changes in cell cycle, little in caspase 3/7 activity, and low levels of cleaved caspase-3 after 24 and 48 h [3]. in vivo: Neither costunolide nor alpha-MGBL affected the blood-ethanol elevation in pylorus-ligated rats or that induced by intraperitoneal and intraduodenal ethanol administration [4]. Costunolide and alpha-MGBL suppressed gastric emptying in rats given 20% ethanol and 1% sodium carboxymethyl cellulose. Clinical trial: N/A