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ATPγS tetralithium salt
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
ATPγS tetralithium salt图片
CAS NO:93839-89-5
包装与价格：
包装价格(元)
5mg电议
10mg电议

产品介绍

化学性质

Physical AppearanceA crystalline solid
StorageStore at -20°C
M.Wt546.98
Cas No.93839-89-5
FormulaC10H12Li4N5O12P3S
SolubilitySoluble in H2O
Chemical NameA name could not be generated for this structure.
Canonical SMILESS=P([O-])([O-])O[P@](O[P@](OC[C@H]1O[C@@H]([C@@H]([C@@H]1O)O)N2C3=NC=NC(N)=C3N=C2)([O-])=O)([O-])=O.[Li+].[Li+].[Li+].[Li+]
运输条件蓝冰运输或根据您的需求运输。
一般建议为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。

资料参考

ATPγS tetralithium salt is an analogue of ATP, acting as a potent agonist of G protein-coupled P2Y2 and P2Y11 receptors (pEC50 = 5.52 for P2Y11) [1].

The P2Y receptors consist of 8 human subtypes, i.e. P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13, and P2Y14, coupled to G protein-dependent and -independent signaling pathways, including ion channels. The P2Y receptors are involved in controlling levels of extracellular nucleotides and nucleosides, and intracellular signaling pathways [1].

In PC 12 cells, preincubation of the cells with norepinephrine (NE) and ATPγS tetralithium salt (1 μM) resulted in a persistent increase in uptake of NE, whilst similar pretreatment with ATP did not show this increase. In the presence of ATP, the activation effect produced by ATPγS tetralithium salt on NE uptake was blocked [2]. In TEA3A1 cells, ATPγS tetralithium salt (0 ~ 200 μM) increased Ca2+ influx in a dose-dependent manner, with ED50 value of about 50 μM. A maximum level of Ca2+ influx was observed when cells were treated with ATPγS tetralithium salt at concentrations above 100 μM. Similar dose-dependent increases in the production of prostaglandin E2(PGE2) were also observed after ATPγS tetralithium salt treatment [3].

References:

[1]. Jacobson K A, Ivanov A A, de Castro S, et al. Development of selective agonists and antagonists of P2Y receptors. Purinergic Signal, 2009, 5(1): 75-89.

[2]. Hardwick J C, Ehrlich Y H, Hendley E D. Extracellular ATP stimulates norepinephrine uptake in PC12 cells. Journal of Neurochemistry, 1989, 53(5):1512-1518.

[3]. Liu P, Lalor D, Bowser S S, et al. Regulation of arachidonic acid release and prostaglandin E2 production in thymic epithelial cells by ATPgammaS and transforming growth factor-alpha. Cellular immunology, 1998, 188(2): 81-88.