Viridicatol 是一种喹啉酮类生物碱，是从内生真菌青霉属的发酵物中分离得到的。
| Cas No. | 14484-44-7 |
| 别名 | 纯绿青霉醇 |
| Canonical SMILES | O=C1C(O)=C(C2=CC(O)=CC=C2)C3=CC=CC=C3N1 |
| 分子式 | C15H11NO3 |
| 分子量 | 253.3 |
| 溶解度 | DMF: soluble,DMSO: soluble,Ethanol: soluble,Methanol: soluble |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Viridicatol is a fungal metabolite that has been found in various Penicillium species as well as Phoma. It suppresses the expression of COX-2 and inducible nitric oxide synthase (iNOS) and inhibits production of nitric oxide and prostaglandin E2 (PGE2) in LPS-stimulated RAW 264.7 and BV2 cells. It also inhibits NF-κB DNA-binding activity, nuclear translocation of NF-κB p65 and p50 heterodimers, and blocks degradation of inhibitor of kappa B α (IκBα) in the cytoplasm of LPS-stimulated RAW 264.7 and BV2 cells. Viridicatol inhibits the growth of F. graminearum in a disc assay. It also inhibits protein tyrosine phosphatase 1B (PTB1B) in vitro (IC50 = 64 μM). |
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