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Micrococcin P1
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Micrococcin P1图片
CAS NO:67401-56-3
包装与价格：
包装价格(元)
500μg电议
2.5mg电议

产品介绍
Micrococcin P1 是一种大环肽抗生素，是一种有效的丙型肝炎病毒 (HCV) 抑制剂，EC50 范围为 0.1-0.5 μM。
Cas No.67401-56-3
别名微球菌素 P1
化学名2’-[(11S,14Z,21S,28S)-14-ethylidene-9,10,11,12,13,14,20,21,27,28-decahydro-28-[(1R)-1-hydroxyethyl]-11-[(1R)-1-hydroxyethyl]-21-(1-methylethyl)-9,12,19,26-tetraoxo-19H,26H-8,5:18,15:25,22:32,29-tetranitrilo-5H,15H-pyrido[3,2-m][1,11,17,24,4,7,20,27]tetrathiatetraazacyclotriacontin-2-yl]-N-[(1Z)-1-[[[(2R)-2-hydroxypropyl]amino]carbonyl]-1-propen-1-yl]-[2,4’-bithiazole]-4-carboxamide
Canonical SMILESO=C(C1=CSC(C2=CSC(C3=NC(C4=CSC([C@H]([C@H](O)C)NC(C5=CSC6=N5)=O)=N4)=C(C7=NC(C(N[C@]([C@H](O)C)([H])C(N/C(C8=NC(C(N[C@H]6C(C)C)=O)=CS8)=C\C)=O)=O)=CS7)C=C3)=N2)=N1)N/C(C(NC[C@H](O)C)=O)=C\C
分子式C48H49N13O9S6
分子量1144.4
溶解度Soluble in ethanol, DlMSO, DMF, methano
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Micrococcin P1 is a macrocyclic peptide antibiotic that functions as an acceptor-site-specific inhibitor of ribosomal protein synthesis, effectively preventing the growth of Gram-positive bacteria without affecting that of Gram-negative bacteria.[1][2]

Reference:
[1]. Carnio, M.C., Hotzel, A., Rudolf, M., et al. The macrocyclic peptide antibiotic micrococcin P(1) is secreted by the food-borne bacterium Staphylococcus equorum WS 2733 and inhibits Listeria monocytogenes on soft cheese. Applied and Environmental Microbiology 66(6), 2378-2384 (2000).
[2]. Mikolajka, A., Liu, H., Chen, Y., et al. Differential effects of thiopeptide and orthosomycin antibiotics on translational GTPases. Chemistry & Biology 18(5), 589-600 (2011)