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Sigma-LIGAND-1
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Sigma-LIGAND-1图片
CAS NO:139652-01-0
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议
20mg电议

产品介绍
Sigma-LIGAND-1是σ受体(sigmareceptor)的选择性配体，在DTG和PPP位点的IC50值分别为16和19nM，在多巴胺受体D2的Ki值为4000nM。
Cas No.139652-01-0
Canonical SMILESO=C1C(C)=C(C2=CC=CC=C2)OC3=CC=C(OCCCCCCN4CCC(O)CC4)C=C13
分子式C27H33NO4
分子量435.56
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Sigma-LIGAND-1 is a selective sigma receptor ligand, has receptor IC50s of 16 nM at the DTG site, 19 nM at the PPP site, and a Ki of 4000 nM at the dopamine D2 receptor.

Administration of Sigma-LIGAND-1 would reverse amphetamine-induced hyperlocomotion in mice, a behavioral model sensitive to antipsychotic compounds. Sigma-LIGAND-1 and its structural analogues have the potential antipsychotic activity[1].

[1]. Erickson RH, et al. (Aminoalkoxy)chromones. Selective sigma receptor ligands. J Med Chem. 1992 May 1;35(9):1526-35.