Tetracycline Hydrochloride

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CAS NO:

64-75-5

包装与价格：

包装	价格(元)
10mM (in 1mL DMSO)	电议
1g	电议
5g	电议

产品介绍

化学性质

Storage	Store at -20°C
M.Wt	480.90
Cas No.	64-75-5
Formula	C₂₂H₂₅ClN₂O₈
Solubility	insoluble in EtOH; ≥12.02 mg/mL in DMSO with gentle warming; ≥57.7 mg/mL in H2O
Chemical Name	(4S,4aS,5aS,6S,12aR)-4-(dimethylamino)-1,6,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide;hydrochloride
Canonical SMILES	CC1(C2CC3C(C(=O)C(=C(C3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O.Cl
运输条件	蓝冰运输或根据您的需求运输。
一般建议	为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。

资料参考

Tetracycline Hydrochloride is an inhibitor of bacterial ribosomes [1].

Tetracycline Hydrochloride is believed to inhibit translation by binding to the 16S rRNA and inhibiting the binding of aminoacyl-tRNA to the mRNA-ribosome complex. However, the exact target site(s) and mechanism(s) of action remain subjects of much debate [1].

Tetracycline Hydrochloride at doses of 0, 10, 25, 50, 75, 150, 225 and 300 μM exhibited increasing antimicrobial effect against resistant strains ofStaphylococcus aureus(S. aureus). The statistically evaluated IC50 values of Tetracycline Hydrochloride againstS. aureus, cadmium-resistantS. aureus, and lead-resistantS. aureusafter first 6 h were 4.8, 3.8, 2.2 μM, respectively [2].

In humans who had minimumPropionibacterium acnes(P. acnes) levels of 10000 colony-forming units per cm²at baseline, Tetracycline Hydrochloride treatment (1000 mg/d, b.i.d., p.o.) over a 6-week period significantly reducedP. acneson both cheeks and forehead after 3 and 6 weeks, but produced little to no residual effect. At 9 weeks,P. acneslevels in the Tetracycline Hydrochloride group had returned to baseline [3].

References:

[1]. Chukwudi C U. rRNA Binding Sites and the Molecular Mechanism of Action of the Tetracyclines. Antimicrobial Agents and Chemotherapy, 2016, 60(8): 4433-4441.

[2]. Chudobova D, Dostalova S, Blazkova I, et al. Effect of ampicillin, streptomycin, penicillin and tetracycline on metal resistant and non-resistant Staphylococcus aureus. International Journal of Environmental Research and Public Health, 2014, 11(3): 3233-3255.

[3]. Leyden J J, Kaidbey K, Gans E H. The antimicrobial effects in vivo of minocycline, doxycycline and tetracycline in humans. Journal of Dermatological Treatment, 1996, 7: 223-225.