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2-Iminobiotin hydrobromide
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
2-Iminobiotin hydrobromide图片
CAS NO:76985-52-9
包装与价格：
包装价格(元)
10mM (in 1mL DMSO)电议
10mg电议
50mg电议

产品介绍
2-Iminobiotin hydrobromide (Guanidinobiotin hydrobromide) 是一种生物素 (维生素 H 或 B7) 类似物。2-Iminobiotin hydrobromide 是一种可逆的 NO 合酶抑制剂，作用于小鼠 iNOS 和大鼠 n-cNOS，Ki 值分别为 21.8 和 37.5 μM。2-Iminobiotin hydrobromide 与低温环境可保护人类神经细胞免受缺氧诱导的细胞损伤。
Cas No.76985-52-9
别名2-亚氨基生物素盐酸盐; Guanidinobiotin hydrobromide
Canonical SMILES[H][C@](CS[C@H]1CCCCC(O)=O)([C@]1([H])N2)NC2=N.Br
分子式C10H18BrN3O2S
分子量324.24
溶解度DMSO: 125 mg/mL (385.52 mM)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

2-Iminobiotin hydrobromide (Guanidinobiotin hydrobromide) is a biotin (vitamin H or B7) analog. 2-Iminobiotin hydrobromide is a reversible nitric oxide synthases inhibitor with Kis of 21.8 and 37.5 μM for murine iNOS and rat n-cNOS, respectively[1]. 2-Iminobiotin hydrobromide superimposes on hypothermia protects human neuronal cells from hypoxia-induced cell damage[2].

[1]. Sup SJ, et al. 2-Iminobiotin is an inhibitor of nitric oxide synthases. Biochem Biophys Res Commun. 1994 Oct 28;204(2):962-8. [2]. Zitta K, et al. 2-Iminobiotin Superimposed on Hypothermia Protects Human Neuronal Cells from Hypoxia-Induced Cell Damage: An in Vitro Study. Front Pharmacol. 2018 Jan 11;8:971.