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10-Cl-BBQ
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
10-Cl-BBQ图片
CAS NO:23982-76-5
包装与价格:
包装价格(元)
5mg电议
25mg电议

产品介绍
Potent aryl hydrocarbon receptor (AhR) agonist; orally bioavailable
Cas No.23982-76-5
Canonical SMILESClC1=CC2=C(N=C3N2C(C4=CC=CC5=C4C3=CC=C5)=O)C=C1
分子式C18H9ClN2O
分子量304.73
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Potent aryl hydrocarbon receptor (AhR) agonist, discovered as a screening hit (IC50 = 2.6 nM). Directly binds CD4+ T cells to induce AhR-dependent Tregs. Suppresses IL-17 production and prevents insulitis in NOD mice. In vivo half llife ~ 2 hours, orally bioavailable.

Punj et al (2014) Benzimidazoisoquinolines: a new class of rapidly metabolized aryl hydrocarbon receptor (AhR) ligands that induce AhR-dependent Tregs and prevent murine graft-versus-host disease. PLoS One 9 e88726 PMID:24586378 |Ehrlich et al (2016) Activation of the aryl hydrocarbon receptor by 10-Cl-BBQ prevents insulitis and effector T cell development independently of Foxp3+ regulatory T Cells in nonobese diabetic mice. J.Immunol. 196 264 PMID:26573835