CAS NO: | 287714-41-4 |
包装 | 价格(元) |
50mg | 电议 |
100mg | 电议 |
Physical Appearance | A solid |
Storage | Store at -20°C |
M.Wt | 481.54 |
Cas No. | 287714-41-4 |
Formula | C22H28FN3O6S |
Solubility | ≥48.2 mg/mL in DMSO; ≥10.78 mg/mL in H2O with ultrasonic; ≥12.4 mg/mL in EtOH with ultrasonic |
Chemical Name | (E,3R,5S)-7-[4-(4-fluorophenyl)-2-[methyl(methylsulfonyl)amino]-6-propan-2-ylpyrimidin-5-yl]-3,5-dihydroxyhept-6-enoic acid |
Canonical SMILES | CC(C)C1=NC(=NC(=C1C=CC(CC(CC(=O)O)O)O)C2=CC=C(C=C2)F)N(C)S(=O)(=O)C |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
Cell experiment:[1] | |
Cell lines | Rat isolated hepatocytes |
Reaction Conditions | 1.12 nM (IC50) |
Applications | Rosuvastatin inhibited the incorporation of sodium [14C]acetate into cholesterol with an IC50 value of 1.12 nM, and its inhibitory activity on cholesterol biosynthesis was approximately 100 times more potent than pravastatin. |
Animal experiment:[1] | |
Animal models | Normolipemic male beagle dogs |
Dosage form | 3 mg/kg/day Administered orally for 14 days |
Applications | In male beagle dogs with normal cholesterol levels, rosuvastatin (3 mg/kg/day) administration for 14 days decreased plasma cholesterol levels by 26%, higher than 18% in the pravastatin treatment group. |
Note | The technical data provided above is for reference only. |
References: 1. Watanabe M, Koike H, Ishiba T, et al. Synthesis and biological activity of methanesulfonamide pyrimidine- and N-methanesulfonyl pyrrole-substituted 3,5-dihydroxy-6-heptenoates, a novel series of HMG-CoA reductase inhibitors. Bioorganic & Medicinal Chemistry, 1997, 5(2): 437-444. |