| CAS NO: | 54-31-9 |
| 包装 | 价格(元) |
| 10mM (in 1mL DMSO) | 电议 |
| 1g | 电议 |
| 5g | 电议 |
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 330.74 |
| Cas No. | 54-31-9 |
| Formula | C12H11ClN2O5S |
| Solubility | insoluble in H2O; ≥13.35 mg/mL in EtOH; ≥14.9 mg/mL in DMSO |
| Chemical Name | 4-chloro-2-(furan-2-ylmethylamino)-5-sulfamoylbenzoic acid |
| Canonical SMILES | C1=COC(=C1)CNC2=CC(=C(C=C2C(=O)O)S(=O)(=O)N)Cl |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
呋塞米(furosemide)是一种Na+/2Cl-/K+协同转运蛋白抑制剂[1].
Na-K-Cl协同转运蛋白(NKCC)是一种协助Na+\K+和Cl-进出细胞的主动转运体.NKCC1在分泌体液的器官里具有重要作用.NKCC2存在于肾脏中,用于从尿液中提取Na+\K+和Cl-[2].
呋塞米(furosemide)是Na+/2Cl-/K+协同转运蛋白的拮抗剂.在成人脑组织中,呋塞米(furosemide)通过抑制细胞肿胀阻断癫痫样活动,并同时抑制活动驱动的细胞间隙变化(ECS)[1].呋塞米(furosemide)抑制外周单核细胞产生和释放细胞因子IL-6\IL-8和TNF-ɑ,从而显示出抗炎活性[3].
在肝硬化患者中,呋塞米(furosemide)抑制钠的作用,并提高心钠素(ANF)和循环内皮素的水平.在新生儿中,呋塞米(furosemide)显著增加醛固酮和内皮素-1的尿排泄[3].
参考文献：
[1]. Hochman DW. The extracellular space and epileptic activity in the adult brain: explaining the antiepileptic effects of furosemide and bumetanide. Epilepsia, 2012, 53 Suppl 1: 18-25.
[2]. Chen H, Sun D. The role of Na-K-Cl co-transporter in cerebral ischemia. Neurol Res, 2005, 27(3): 280-286.
[3]. Prandota J. Furosemide: progress in understanding its diuretic, anti-inflammatory, and bronchodilating mechanism of action, and use in the treatment of respiratory tract diseases. Am J Ther, 2002, 9(4): 317-328.
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