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SM 324405
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
SM 324405图片
CAS NO:677773-91-0
包装与价格：
包装价格(元)
10mg电议
50mg电议

产品介绍
SM 324405 是一种 TLR7 激动剂前药 (EC50 \u003d 50 nM)，对人 TLR7 和大鼠 TLR7 的 pEC50 值分别为 7.3 和 6.6。
Cas No.677773-91-0
Canonical SMILESNC1=NC(OCCCC)=NC(N2CC3=CC=CC(CC(OC)=O)=C3)=C1NC2=O
分子式C19H23N5O4
分子量385.42
溶解度DMSO: 100 mM
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Potent TLR7 agonist (EC50 = 50 nM). Exhibits selectivity for TLR7 over TLR8. Induces IFN-α and -γ expression in human PBMCs and mouse splenocytes, and inhibits IL-5 production in human PBMCs in vitro. Rapidly metabolized to acid metabolite (t½ = 2.6 min in human plasma).

Kurimoto et al (2010) Synthesis and biological evaluation of 8-oxoadenine derivatives as toll-like receptor 7 agonists introducing the antedrug concept. J.Med.Chem. 53 2964 PMID:20232824 |Biffen et al (2012) Biological characterization of a novel class of toll-like receptor 7 agonists designed to have reduced systemic activity. Br.J.Pharmacol. 166 573 PMID:22122192