As-358 hydrochloride

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CAS NO:

2374723-26-7

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

As-358 (hydrochloride) 对埃博拉病毒 (Ebola virus) 和马尔堡病毒 (Marburg virus) 具有抑制活性，IC₅₀分别为 9.1 μM 和 18.1 μM，同时也具有良好的体内安全性。

生物活性

As-358 (hydrochloride) has inhibitory effects againstEbola virusandMarburg viruswithIC₅₀s of 9.1 μM and 18.1 μM, as well as exhibits goodin vivosafety^[1].

IC₅₀& Target

IC₅₀: 9.1 μM (Ebola virus), 18.1 μM (Marburg virus)^[1]

体外研究
(In Vitro)

As-358 (hydrochloride) (compound 3b·HCl) (0-500 μM) exhibits inhibitory activities against EBOV and MARV^[1].

Cell Proliferation Assay

Cell Line:	Vero (infected with EBOV and MARV)^[1]
Concentration:	0-500 μM
Incubation Time:	10 days
Result:	Exhibits inhibitory activities against EBOV and MARV, with IC₅₀s of 18.1 ± 9.3 μM and 9.1 ± 2.1 μM, SI values of 15 and 31, respectively.

体内研究
(In Vivo)

As-358 (hydrochloride) (0.14-1.08 g/kg; IG; single) exhibits no toxicity to adult mice with intragastric administration^[1].

Animal Model:	ICR mice^[1]
Dosage:	1.08, 0.44, 0.27, and 0.14 g/kg
Administration:	IG; single (observed for 7 days)
Result:	Exhibited no toxicity to adult mice with intragastric administration, and the LD₅₀>1000 mg/kg.

分子量

329.91

Formula

C₁₈H₃₂ClNO₂

CAS 号

2374723-26-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.