Doxorubicin (Hydroxydaunorubicin), a cytotoxic anthracyclineantibiotic, is an anti-cancer chemotherapy agent. Doxorubicin inhibitstopoisomeraseIIwith anIC₅₀of 2.67 μM, thus stopping DNA replication. Doxorubicin reduces basal phosphorylation ofAMPKand its downstream targetacetyl-CoA carboxylase. Doxorubicin inducesapoptosisandautophagy^[1][2]. Doxorubicin inhibits humanDNAtopoisomeraseIwith anIC₅₀of 0.8 μM^[3].

Combination of Doxorubicin (Hydroxydaunorubicin) and Simvastatin in the highest tested concentrations (2 μM and 10 μM, respec-tively) kills 97% of the Hela cells^[4].

Mice bearing PC3 xenografts are injected with 2, 4 or 8 mg/kg Doxorubicin (Hydroxydaunorubicin) and tumor volume is measured over time. A dose of 2 mg/kg does not affect tumor growth while higher dosages delay tumor growth initially (p<0.05 at days 18 and 22), 4 mg/kg or 8 mg/kg Doxorubicin significantly reduces levels of c-FLIP in PC3 xenografts^[5]. A single intraperitoneal injection 10 mg/kg (Doxorubicin 1) is administered in rats, 10 daily intraperitoneal injections of 1 mg/kg (Doxorubicin 2), or in 5 weekly intraperitoneal injections of 2 mg/kg (Doxorubicin 3). An 80% mortality rate is observed at day 28 in Doxorubicin 1, whereas Doxorubicin 2 and Doxorubicin 3 reached 80% mortality at days 107 and 98, respectively. Fractional shortening decreased by 30% at week 2 in Doxorubicin DOX1, 55% at week 13 in Doxorubicin 2, and 42% at week 13 in Doxorubicin 3^[6].

543.52

C₂₇H₂₉NO₁₁

23214-92-8

阿霉素；多柔比星

• Quinones
• Anthraquinones

• Phenols
• Polyphenols

Streptomyces peucetius.

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• 1.

  Doxorubicin (dissolved with distilled water) is incorporated into 0.035% CaCl₂solution^[5].

• 2.

  Doxorubicin (Adriamycin) is prepared in vehicle (PBS)^[6].