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Prochlorperazine(maleate)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Prochlorperazine(maleate)图片
CAS NO:84-02-6
包装与价格:
包装价格(元)
50mg电议
100mg电议
250mg电议
500mg电议

产品介绍
Cas No.84-02-6
别名丙氯拉嗪
Canonical SMILESCN1CCN(CCCN2C(C=CC=C3)=C3SC4=C2C=C(Cl)C=C4)CC1.O=C(O)/C=C\C(O)=O.O=C(O)/C=C\C(O)=O
分子式C20H24ClN3S•2C4H4O4
分子量606.1
溶解度DMSO: 10 mg/ml,DMSO:PBS (pH 7.2)(1:5): 0.16 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Prochlorperazine is a dopamine D2 receptor antagonist with Ki values of 4.7 and 2.9 nM for rat recombinant D2 receptors in CHO cells and rat striatal membranes, respectively. It also binds to rat recombinant D3 receptors expressed in CHO cells (Ki = 35 nM) and to the serotonin (5-HT) receptor subtype 5-HT3 in N1E-115 mouse neuroblastoma cell membranes (Ki = 1,200 nM). Prochlorperazine (2 mg/kg) increases the latency to paw licking in a hot plate test, indicating analgesia, an effect that is blocked by antisense oligonucleotides against the M1 muscarinic receptor. It also inhibits emesis induced by apomorphine in dogs (ED50 = 0.34 mg/kg). Formulations containing prochlorperazine have been used in the treatment of psychotic disorders and as antiemetics.