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Trastuzumab deruxtecan(solution)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
CAS NO:1826843-81-5
包装与价格：
包装价格(元)
1mg (10mg/mL * 100 μL in Aqueous solution)电议
5mg (10mg/mL * 500 μL in Aqueous solution)电议

产品名称
DS-8201 (solution)
DS-8201a (solution)
产品介绍
Trastuzumab deruxtecan (DS-8201a) (solution) 是一种抗人表皮生长因子受体 2 (HER2) 抗体-药物偶联物 (ADC)。Trastuzumab deruxtecan (solution) 由人源化抗 HER2 抗体，酶促裂解的肽接头和拓扑异构酶 I 抑制剂组成。Trastuzumab deruxtecan (solution) 可用于 HER2 阳性乳腺癌和胃癌的研究。
生物活性

Trastuzumab deruxtecan (DS-8201a) (solution) is an anti-human epidermal growth factor receptor 2 (HER2) antibody-drug conjugate (ADC). Trastuzumab deruxtecan (solution) is composed of a humanized anti-HER2 antibody, an enzymaticallycleavablepeptide-linker, and atopoisomeraseI inhibitor. Trastuzumab deruxtecan (solution) can be used for the research of HER2-positive breastcancerand gastriccancer[1][2].

体外研究
(In Vitro)

Trastuzumab deruxtecan (1 pM-10 nM; 5 days) (solution) inhibits the growth of HER2-positive KPL-4 cells, with an IC50of 109.7 pM[2].
Trastuzumab deruxtecan (10 nM; 5 days) (solution) shows bystander killing effects in HER2-negative MDA-MB-468 cells[2].

Cell Viability Assay[2]

Cell Line:KPL-4 and MDA-MB-468 cells
Concentration:1, 10, 100, 1000, 10000 pM
Incubation Time:5 days
Result:Killed HER2-positive KPL-4 cells only.
体内研究
(In Vivo)

Trastuzumab deruxtecan (3 mg/kg; a single i.v.) (solution) shows antitumor activity against not only HER2-positive tumors but also HER2-negative tumors under the co-inoculated condition[2].
Trastuzumab deruxtecan (10 mg/kg; i.v. on days 0 and 7) (solution) inhibits the tumor growth in in EMT6-hHER2 syngeneic mouse model[3].

Animal Model:Female BALB/c nude mice injected with NCI-N87 and MDA-MB-468-Luc cells[2]
Dosage:3 mg/kg
Administration:A single i.v.
Result:Almost all of the HER2-positive and HER-negative cells disappeared and there were little or no cancer cells remaining in the tumors.
Clinical Trial
性状

Liquid

CAS 号

1826843-81-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.