Trastuzumab emtansine

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1018448-65-1

包装与价格：

包装	价格(元)
1mg	电议
5mg	电议
10mg	电议
50mg	电议
100mg	电议

产品名称

曲妥珠单抗-美坦新偶联物
Ado-Trastuzumab emtansine
PRO132365
T-DM 1

产品介绍

Trastuzumab emtansine (Ado-Trastuzumab emtansine) 是一种抗体偶联药物 (ADC)，其结合了 HER2 靶向的曲妥珠单抗的抗肿瘤特性以及微管抑制剂 DM1 的细胞毒活性。Trastuzumab emtansine 可用于晚期乳腺癌的研究。

生物活性

Trastuzumab emtansine (Ado-Trastuzumab emtansine) is an antibody-drug conjugate (ADC) that incorporates the HER2-targeted antitumor properties of trastuzumab with the cytotoxic activity of the microtubule-inhibitory agent DM1 (derivative of maytansine). Trastuzumab emtansine can be used for the research of advanced breastcancer^[1]^[2].

体外研究
(In Vitro)

Trastuzumab emtansine (2 μg/mL; 3 d) significantly inhibits the proliferation of epithelial ovarian cancer (EOC) cells^[2].

体内研究
(In Vivo)

Trastuzumab emtansine (15 mg/kg; i.v. three to five times weekly for 3 weeks) exhibits significantly anti-tumor effect in mice^[2].

Animal Model:	CB-17/SCID mice (6 weeks) were injected with OVA10 cells^[2]
Dosage:	15 mg/kg
Administration:	I.v. three to five times weekly for 3 weeks
Result:	Showed remarkable inhibition of tumor growth in mice and was well tolerated.

Clinical Trial

性状

Solid

CAS 号

1018448-65-1

中文名称

曲妥珠单抗-美坦新偶联物

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Store at 4°C, do not freeze