Tamrintamab pamozirine

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2148334-68-1

包装与价格：

包装	价格(元)
1mg	电议
5mg	电议

产品名称

DC-1728001
SC-003
SC-003 ADC

产品介绍

Tamrintamab pamozirine (DC-1728001; SC-003; SC-003 ADC) 是一种靶向二肽酶 3 (DPEP3或MBD3) 的Antibody-Drug Conjugate (ADC)。DPEP3是一种糖基磷脂酰肌醇锚定金属肽酶，在卵巢肿瘤中过度表达。Tamrintamab pamozirine 可特异性结合表达 DPEP3 的细胞产生细胞毒性，Tamrintamab pamozirine 可用于卵巢癌的研究。

生物活性	Tamrintamab pamozirine (DC-1728001; SC-003; SC-003 ADC) anAntibody-Drug Conjugate (ADC)targeting todipeptidase 3(DPEP3orMBD3).DPEP3is a glycosyl phosphatidylinositol anchored metallopeptidase that is overexpressed in ovarian tumors. Tamrintamab pamozirine can specifically bind DPEP3-expressing cells to produce cytotoxicity. Tamrintamab pamozirine can be used in ovariancancerresearch.^[1].
IC₅₀& Target	Dipeptidase 3 (DPEP3, MBD3)^[1]
体外研究 (In Vitro)	Tamrintamab pamozirine can be cleaved to pyrrolobenzodiazepine (PBD) dimers to specifically bind DPep3-expressing cells. After internalization, the release of PBD warheads through degradation of the antibody component lysosome induces cytotoxicity^[2].
体内研究 (In Vivo)	Tamrintamab pamozirine (single dose) induced tumor regression in DPEP3-positive HGSC transplantation models (PDX), including platinum-resistant PDX models. Moreover, the antitumor effect of Tamrintamab pamozirine is mediated by a significant reduction in the frequency of tumor-originating cells (TIC)^[2].
CAS 号	2148334-68-1
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.