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Elbasvir
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Elbasvir图片
CAS NO:1370468-36-2
规格:≥98%
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议
250mg电议
500mg电议

产品介绍
理化性质和储存条件
Molecular Weight (MW) 882.02
Formula C49H55N9O7
CAS No. 1370468-36-2
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO:>100 mg/mL (113.4 mM)
Water: <1mg/mL
Ethanol:<1mg/mL
Chemical NameDimethyl ((2S,2'S)-((2S,2'S)-(((S)-6-phenyl-6H-benzo[5,6][1,3]oxazino[3,4-a]indole-3,10-diyl)bis(1H-imidazole-5,2-diyl))bis(pyrrolidine-2,1-diyl))bis(3-methyl-1-oxobutane-1,2-diyl))dicarbamate
Synonyms MK8742; MK-8742; trade name Zepatier; MK 8742
实验参考方法
In Vitro

In vitro activity: Elbasvir shows potent activity against genotype 1a and 1b replicons, with EC90 of 0.006 nM for both the wild-type 1a_H77 and 1b_con1 replicons. Elbasvir inhibits genotype 3 replicons with EC90 of 0.12 nM. Elbasvir (0.06 nM, 0.6 nM, and 6 nM) demonstrates dose-dependent suppression of resistant genotype 1a replicons, illustrated by the reductions in colony counts at higher doses. Elbasvir is highly potent against HCV replicons bearing NS5A sequences from GT1a, -1b, -2a(31L), -3a, -4a, -5a, and -6, with EC50s in the low-picomolar range.


Kinase Assay: Elbasvir is a HCV NS5A inhibitor which prevents hepatitis C viral RNA replication and virion assembly with median EC50 values ranging from 0.2 to 3600 pmol/L, based on genotypes.


Cell Assay: Elbasvir (formerly known as MK-8742; MK8742; trade name Zepatier) is a potent NS5A (nonstructural protein 5A) inhibitor with anti-HCV (hepatitis C virus) activities against different HCV genotypes.

In Vivo
Animal model
Formulation & Dosage
References Antimicrob Agents Chemother. 2015 Nov;59(11):6922-9.