NU 7026 (LY293646) is a novel specificDNA-PKinhibitor withIC₅₀of 0.23 μM, also inhibitsPI3KwithIC₅₀of 13 μM.

NU7026 (10 μM) potentiates ionizing radiation (IR) cytotoxicity [potentiation factor at 90% cell kill (PF₉₀)=1.51±0.04] in exponentially growing DNA-PK proficient but not deficient cells^[1]. NU7026 synergistically sensitizes I83 cells to Chlorambucil (CLB) 3.5-fold^[2].NU7026, a novel inhibitor of the DNA repair enzyme DNA-dependent protein kinase (DNA-PK). At a dose of 10 μM, which is nontoxic to cellsper se, a minimum NU7026 exposure of 4 h in combination with 3 Gy radiation is required for a significant radiosensitisation effect in CH1 human ovarian cancer cells^[3].
Solutionin vitro: NU7026 is dissolved in anhydrous DMSO. NU7026 is added to cells to a final concentration of 0.25% DMSO (v/v)^[4].

NU7026, a novel inhibitor of the DNA repair enzyme DNA-dependent protein kinase (DNA-PK). Following intravenous administration to mice at 5 mg/kg, NU7026 underwent rapid plasma clearance (0.108 L/h) and this is largely attributed to extensive metabolism. Bioavailability following interperitoneal (i.p.) and p.o. administration at 20 mg/kg is 20 and 15%, respectively^[3].
Solutionin vivo:
NU7026 is formulated in 10% DMSO and 5% Tween 20 in saline (i.p. and p.o.) (Mice)^[3].
NU7026 is formulated in 10% ethanol, 25% PEG 200 and 5% Tween 20 in saline (i.v.)^[3].

281.31

Solid

C₁₇H₁₅NO₃

154447-35-5

Room temperature in continental US; may vary elsewhere.

DMSO : 2.5 mg/mL(8.89 mM;Need ultrasonic)

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