4E1RCat

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4E1RCat

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

328998-25-0

包装与价格：

包装	价格(元)
10 mM * 1 mL in DMSO	电议
5mg	电议
10mg	电议
50mg	电议
100mg	电议
200mg	电议
500mg	电议

产品介绍

4E1RCat 是一种 cap 依赖性翻译抑制剂，能够抑制eIF4E:eIF4GI相互作用，IC₅₀值约为 4 μM。

生物活性

4E1RCat is an inhibitor of cap-dependent translation, and inhibitseIF4E:eIF4GIinteraction, with anIC₅₀an of ~4 μM.

IC₅₀& Target

eIF4

体外研究
(In Vitro)

4E1RCat is an inhibitor of eIF4E:eIF4GI interaction, with an IC₅₀an of ~4 μM. 4E1RCat binding to eIF4E also interferes with eIF4G and 4E-BP binding. 4E1RCat inhibits ribosome recruitment to mRNA in a cap-dependent manner^[1]. 4E1RCat blocks the capped mRNA translation, and the translation is activated by CDK1/CYCB1. Nearly all new protein synthesis in both mitosis and interphase is cap-dependent and -sensitive to 4E1RCat treatment, in HeLa and U2OS cells^[2].

体内研究
(In Vivo)

4E1RCat (15 mg/kg, i.p.) affacts chemosensitivity of Pten^+/-Eμ-Myc tumors in mice. 4E1RCat (15 mg/kg, i.p.) sensitizes Pten^+/-Eμ-Myc and Tsc2^+/-Eμ-Myc lymphomas to the cytotoxic effects of doxorubicin (Dxr), and 4E1RCat targets translation in mice^[1].

分子量

478.45

性状

Solid

Formula

C₂₈H₁₈N₂O₆

CAS 号

328998-25-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : 18.33 mg/mL(38.31 mM;Need ultrasonic)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	2.0901 mL	10.4504 mL	20.9008 mL
5 mM	0.4180 mL	2.0901 mL	4.1802 mL
10 mM	0.2090 mL	1.0450 mL	2.0901 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。