Episilvestrol

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Episilvestrol

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

697235-39-5

包装与价格：

包装	价格(元)
10 mM * 1 mL in DMSO	电议
1mg	电议
5mg	电议
10mg	电议

产品介绍

Episilvestrol 是 silvestrol 的衍生物，从Aglaia perviridis中分到，能够抑制eIF4A靶作用的转录过程。

生物活性

Episilvestrol is a derivative of silvestrol, isolated from the fruits and twigs ofAglaia perviridis, and is a specificeIF4A-targeting translation inhibitor, with antitumor activity.

IC₅₀& Target

eIF4

体外研究
(In Vitro)

Episilvestrol is a specific eIF4A-targeting translation inhibitor, with antitumor activity^[1]. Episilvestrol is cytotoxic activity against several human cancer cell lines, such as Lu1, LNCaP, MCF-7 and HUVEC cells, with ED₅₀s of 3.8, 3.8, 5.5 and 15.3 nM, respectively^[2]. The GI₅₀s of Episilvestrol against the cell proliferation of NCI-H460 and MCF-7 cels are 17.96 nM and 17.96 nM after first test and 15.6 nM and 18.7 nM after 2 months via SRB assay. Episilvestrol also suppresses HK1 cells and EBV-positive C666.1 NPC cells^[3].

分子量

654.66

性状

Solid

Formula

C₃₄H₃₈O₁₃

CAS 号

697235-39-5

结构分类

Others

来源

Plants
Meliaceae
Aglaia perviridisHiern

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : 25 mg/mL(38.19 mM;Need ultrasonic)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	1.5275 mL	7.6376 mL	15.2751 mL
5 mM	0.3055 mL	1.5275 mL	3.0550 mL
10 mM	0.1528 mL	0.7638 mL	1.5275 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。