GRP78-IN-3

立即咨询

GRP78-IN-3

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2707510-30-1

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

GRP78-IN-3 是一种选择性Grp78 (HSPA5)抑制剂，IC₅₀为 0.59 μM。GRP78-IN-3 对 HspA5 的选择性是 HspA9 的 7 倍 (IC₅₀为 4.3 μM)，是 HspA2 的 20 倍以上 (IC₅₀为 13.9 μM)。

生物活性

GRP78-IN-3 is a selectiveGrp78 (HSPA5)inhibitor with anIC₅₀of 0.59 μM. GRP78-IN-3 is 7-fold selective forHspA5compared to HspA9 (IC₅₀of 4.3 μM) and >20-fold selective forHspA5compared to HspA2 (IC₅₀of 13.9 μM)^[1].

IC₅₀& Target^[1]

HSPA5

0.59 μM (IC₅₀)

体外研究
(In Vitro)

GRP78-IN-3 (compound 8) is a potent small-molecule-competitive inhibitor of Hsp70 substrate binding. GRP78-IN-3 (0.1-100 μM) shows more potent inhibition efffects in a spheroid tumor model (U251 glioblastoma cells and H520 lung cancer cells)^[1].

分子量

342.42

Formula

C₁₇H₁₈N₄O₂S

CAS 号

2707510-30-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.