Gap19

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Gap19

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1507930-57-5

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

Gap19 是一种衍生自 Cx43 细胞质环 (CL) 九个氨基酸的肽，一种有效的，选择性连接蛋白 43 (Cx43) 半通道阻滞剂。Gap19 可以防止 C 末端 (CT) 与 CL 的分子内相互作用。Gap19 不阻断 GJ 通道或 Cx40/pannexin-1 半通道。Gap19 对心肌具有保护作用。

生物活性

Gap19, a peptide derived from nineamino acidsof the Cx43 cytoplasmic loop (CL), is a potent and selectiveconnexin 43 (Cx43) hemichannelblocker. Gap19 inhibits hemichannels caused by preventing intramolecular interactions of the C-terminus (CT) with the CL. Gap19 is not blocking GJ channels or Cx40/pannexin-1 hemichannels. Gap19 has protective effects against myocardial^[1]^[2].

IC₅₀& Target

Cx43 Hemichannel^[1]

体外研究
(In Vitro)

Gap19 (250 μM; for 30 min ) decreases mitochondrial potassium uptake^[1].
Gap19 (400 μM) inhibits unitary hemichannel currents in HeLa-Cx43 cells^[2].
Gap19 (100 μM) inhibits hemichannel unitary currents in ventricular cardiomyocytes^[2].
Gap19 (250 μM, 30 min) protects against myocardial ischemia/reperfusion injury in vitro and in vivo^[2].

体内研究
(In Vivo)

Gap19 (iv; 25 mg/kg; 10 min before ligation) significantly reduces the infarct size by approximately one-fifth^[2].

Animal Model:	C57/BL6 mice^[2]
Dosage:	25 mg/kg
Administration:	IV; 10 min before ligation
Result:	Significantly reduced the infarct size by approximately one-fifth.

分子量

1161.44

Formula

C₅₅H₉₆N₁₄O₁₃

CAS 号

1507930-57-5

Sequence Shortening

KQIEIKKFK

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.