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GF 109203X
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
GF 109203X图片
CAS NO:133052-90-1
包装与价格:
包装价格(元)
10mg电议
25mg电议
50mg电议
100mg电议
10mM * 1mL in DMSO电议

产品名称
GF-109203X, GF109203X, GO6850, GO-6850, Bisindolylmaleimide I
产品介绍

生物活性

GF 109203X是一种有效且选择性的蛋白激酶C抑制剂,对α和β1亚型具有选择性(对于α,β1,δ,δ,ε和ζ亚型,IC50分别为0.0084、0.0180、0.210、0.132和5.8μM)。对MLCK,PKG和PKA具有选择性(IC50值分别为0.6、4.6和33μM)。5-HT3受体的强效拮抗剂(Ki = 29.5 nM)。= 29.5 nm)。

Targets

TargetValue
PKCβ2IC50: 16nM
PKCβ1IC50: 17nM
PKCαIC50: 20nM
PKCγIC50: 20nM
PDGFRIC50: 65μM
EGFRIC50: >100μM
Insulin ReceptorIC50: >100μM

化学数据

目录号A13197
作用机制Inhibitor (抑制剂)
M. Wt412.49
FormulaC25H24N4O2
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.133052-90-1
SynonymsGF-109203X, GF109203X, GO6850, GO-6850, Bisindolylmaleimide I
SMILESCN(C)CCCN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=CNC5=CC=CC=C54

溶解度

In vitroDMSO70 mg/mL (169.7 mM)
WaterInsoluble
EthanolInsoluble
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM24.24 mL121.22 mL242.43 mL
0.5 mM4.85 mL24.24 mL48.49 mL
1 mM2.42 mL12.12 mL24.24 mL
5 mM0.48 mL2.42 mL4.85 mL

*The above data is based on the productmolecular weight 412.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.