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Eliprodil
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Eliprodil图片
CAS NO:119431-25-3
包装与价格：
包装价格(元)
10mg电议
50mg电议

产品介绍
Eliprodil(SL-820715) 是一种非竞争性 NR2B-NMDA 受体拮抗剂 (IC50=1 uM)，对含 NR2A 和 NR2C 的受体作用较小 (IC50>100 uM)。
Cas No.119431-25-3
别名依利罗地,SL-820715
化学名(R)-1-(4-chlorophenyl)-2-(4-(4-fluorobenzyl)piperidin-1-yl)ethanol
Canonical SMILESClC1=CC=C(C=C1)[C@H](CN2CCC(CC(C=C3)=CC=C3F)CC2)O
分子式C20H23ClFNO
分子量347.86
溶解度DMF: 10mg/mL,DMSO: 2mg/mL,Ethanol: 2mg/mL
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Eliprodil(SL-820715) is a non-competitive NR2B-NMDA receptor antagonist(IC50=1 uM), less potent for NR2A- and NR2C-containing receptors(IC50>100 uM).IC50 value:Target: NR2B-NMDA antagonistHuman N-type Ca2+ channel currents were inhibited by ifenprodil and eliprodil with IC50 values of 50 microM and 10 microM respectively whereas P-type Ca2+ channel currents were inhibited reversibly by ifenprodil and eliprodil with approximate IC50 values of 60 microM and 9 microM respectively. eliprodil (1 microm) produced a moderate reverse rate-dependent prolongation of the action potential duration (7.4+/-1.5, 8.9+/-2.1 and 9.9+/-1.8% at cycle lengths of 300, 1000 and 5000 ms, respectively; n=9).

References:
[1]. Bath CP, et al. The effects of ifenprodil and eliprodil on voltage-dependent Ca2+ channels and in gerbil global cerebral ischaemia. Eur J Pharmacol. 1996 Mar 28;299(1-3):103-12.
[2]. Lengyel C, et al. Effect of a neuroprotective drug, eliprodil on cardiac repolarisation: importance of the decreased repolarisation reserve in the development of proarrhythmic risk. Br J Pharmacol. 2004 Sep;143(1):152-8.