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E-4031 dihydrochloride
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
E-4031 dihydrochloride图片
CAS NO:113559-13-0
包装与价格：
包装价格(元)
5mg电议
10mg电议

产品介绍
KV11.1 (hERG) channels blocker
Cas No.113559-13-0
别名N-[4-[[1-[2-(6-甲基-2-吡啶基)乙基]-4-哌啶基]羰基]苯基]甲烷磺酰胺二盐酸盐
化学名N-(4-(1-(2-(6-methylpyridin-2-yl)ethyl)piperidine-4-carbonyl)phenyl)methanesulfonamide dihydrochloride
Canonical SMILESO=C(C(C=C1)=CC=C1NS(=O)(C)=O)C2CCN(CCC3=NC(C)=CC=C3)CC2.Cl.Cl
分子式C21H27N3O3S.2HCl
分子量474.44
溶解度DMF: 0.3 mg/ml,DMSO: 25 mg/ml,PBS (pH 7.2): 10 mg/ml
储存条件Desiccate at RT
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

E-4031 is a class III antiarrhythmic agent which selectively blocks hERG potassium channel.

References:
[1]. Nalos L, et al. Comparison of the IKr blockers moxifloxacin, dofetilide and E-4031 in five screening models of pro-arrhythmia reveals lack of specificity of isolated cardiomyocytes. Br J Pharmacol. 2012 Jan;165(2):467-78.
[2]. Verheijck EE, et al. Effects of delayed rectifier current blockade by E-4031 on impulse generation in single sinoatrial nodal myocytes of the rabbit. Circ Res. 1995 Apr;76(4):607-15.
[3]. Izumi-Nakaseko H, et al. Effects of selective IKr channel blockade by E-4031 on ventricular electro-mechanical relationship in the halothane-anesthetized dogs. Eur J Pharmacol. 2014 Oct 5;740:263-70.
[4]. Izumi D, et al. Effects of bepridil versus E-4031 on transmural ventricular repolarization and inducibility of ventricular tachyarrhythmias in the dog. Pacing Clin Electrophysiol. 2010 Aug;33(8):950-9.