APJ receptor agonist 5 (compound 3) is a potent and orally active agonist ofapelin receptor(APJ) with anEC₅₀of 0.4 nM. APJ receptor agonist 5 displays excellent pharmacokinetic profiles in the rodent heart failure (HF) model. APJ receptor agonist 5 also shows an acceptable safety profile in preclinical toxicology studies. APJ receptor agonist 5 leads to improved cardiac function and can be used for researching the HF disease^[1].

479.52

C₂₆H₂₉N₃O₆

2135514-20-2

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