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Bombesin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:31362-50-2
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品名称
蛙皮素
产品介绍
Bombesin 是一种十四肽,在胃泌素释放和 G 蛋白受体活化中起重要作用。
生物活性

Bombesin, a tetradecapeptide, plays an important role in the release of gastrin and the activation of G-protein receptors[1].

体外研究
(In Vitro)

Bombesin is a tetradecapeptide with a COOH terminus ending in Gly-His-Leu-Met-NH2 and subsequently is shown to closely resemble two mammalian bombesin -related peptides, gastrin-releasing peptide (GRP) and neuromedin B (NMB)[1]. Bombesin is found to have stimulatory effects upon gastric and pancreatic secretions, release of gastrointestinal hormones, gallbladder contraction and bronchoconstriction. It is present in amphibian gastric endocrine cells, avian proventriculus endocrine cells and avian brain. In mammals it is present mainly in nerve cells and fibers. The only mammalian endocrine cell shown to date to have bombesin is the P-cell in fetal lung. Bombesin is also found in mammalian brain, with its highest concentration in the hypothalamus[2]. Bombesin is shown to be a potent mitogen for Swiss 3T3 cells. In the presence of a low concentration (3.5%) of serum, bombesin stimulates 3T3 cell proliferation. In serum-free medium, bombesin induces DNA synthesis in the absence of any other added growth factor (IC50=1 nM)[3].

分子量

1619.85

性状

Solid

Formula

C71H110N24O18S

CAS 号

31362-50-2

Sequence

{Glp}-Gln-Arg-Leu-Gly-Asn-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH2

Sequence Shortening

{Glp}-QRLGNQWAVGHLM-NH2

中文名称

蛙皮素

结构分类
  • Others
来源

the skin of the European amphibians Bombina and Alytes

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture and light

Powder-80°C2 years
-20°C1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性数据
In Vitro: 

H2O : 1.43 mg/mL(0.88 mM;Need ultrasonic)