CCR6 antagonist 1 是一种CCR6拮抗剂，可抑制CCL20/CCR6信号通路。 CCR6 antagonist 1 可用于自身免疫介导的炎症性疾病的研究，如炎症性肠病 (IBDs)。
| 生物活性 | CCR6 antagonist1 is aCCR6antagonist that inhibits theCCL20/CCR6axis.CCR6 antagonist1 can be used in the research of autoimmune-mediated inflammatory diseases, such as inflammatory bowel diseases (IBDs)[1]. |
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体外研究
(In Vitro) | CCR6 antagonist 1 (compound 1b, 50 μM, 3 h) blocks the CCL20-induced CD4+T cell migration[1].
CCR6 antagonist 1 (30 nM-300 μM, 20 min) inhibits miniGi recruitment to CCR6 induced by CCL20, and β-arrestin-1 recruitment to CCR6 and CCR5 by CCL20 and CCL5 (5 nM), respectively[1].
Cell Migration Assay[1] | Cell Line: | CCL20 (500 ng/mL)-induced CCR6+CD4+T cell | | Concentration: | 0.5, 5, 50 μM | | Incubation Time: | 3 h | | Result: | Inhibited CCL20-induced cell migration at 50 μM. |
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体内研究
(In Vivo) | CCR6 antagonist 1 (compound 1b, 1 mg/kg, s.c., twice daily for 3 days) alleviates TNBS-induced inflammatory responses in mice[1].
CCR6 antagonist 1 (1 mg/kg, s.c., twice, before and after zymosan treatment) shows anti-inflammatory effects
in Zymosan-induced peritonitis mice[1].
| Animal Model: | Murine model of colitis (5 mg/mouse TNBS-induced)[1] | | Dosage: | 1 mg/kg | | Administration: | Subcutaneous injection (s.c.), twice daily for 3 days. | | Result: | Improved mice general conditions, attenuated macroscopic injury and counteracted neutrophils infiltration, both in the colon and in lungs. |
| Animal Model: | Zymosan-induced peritonitis mice[1] | | Dosage: | 1 mg/kg | | Administration: | Subcutaneous injection (s.c.), twice, before and after zymosan treatment | | Result: | Significantly reduced the total protein content and myeloperoxidase activity in the peritoneal lavage. |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | | Powder | -20°C | 3 years | | In solvent | -80°C | 6 months | | -20°C | 1 month |
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| 溶解性数据 | In Vitro: DMSO : ≥ 100 mg/mL(313.20 mM) *"≥" means soluble, but saturation unknown. 配制储备液 | 1 mM | 3.1320 mL | 15.6602 mL | 31.3205 mL | | 5 mM | 0.6264 mL | 3.1320 mL | 6.2641 mL | | 10 mM | 0.3132 mL | 1.5660 mL | 3.1320 mL |
*请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。 |
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