PSB-12379 disodium, a nucleotide analogue, is a potentEcto-5'-Nucleotidase(CD73) inhibitor withK_is of 9.03 nM (rat) and 2.21 nM (human)^[1][2].

Ki: 9.03 nM (rat), 2.21 nM (human) (Ecto-5’-Nucleotidase)^[1].

Metabolism: Only a small percentage (<23%) of PSB-12379 (10g) is metabolized under the applied conditions, while >77% of the compounds are recovered unchanged after a long incubation for 8 h. PSB-12379 (10g) is somewhat less stable, and 56% are metabolized within 8 h. Hydrolytic cleavage of the glycosidic bond, which is a typical phase I reaction of nucleosides and nucleotides, was observed as the main reaction^[1].

573.34

C₁₉H₂₃N₅Na₂O₉P₂

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.