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AMY-101 TFA
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
CAS NO:1789738-04-0
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议
50mg电议
100mg电议

产品名称
Cp40 TFA
产品介绍
AMY-101 TFA (Cp40 TFA) 是补体 C3 的肽类抑制剂 (KD= 0.5 nM)，可抑制非人类灵长类动物自然发生的牙周炎。AMY-101 TFA (Cp40 TFA) 在 COVID-19 重症肺炎合并全身超炎症模型中具有良好的抗炎活性。
生物活性

AMY-101 TFA (Cp40 TFA), a peptidic inhibitor of the centralcomplement componentC3(KD= 0.5 nM), inhibits naturally occurring periodontitis in non-human primates (NHPs). AMY-101 (Cp40) exhibits a favorable anti-inflammatory activity in models with COVID-19 severe pneumonia with systemic hyper inflammation[1][2].

IC50& Target

KD: 0.5 nM (C3)[1].

体内研究
(In Vivo)

AMY-101 can improve the periodontal condition of NHPs with natural chronic periodontitis[1].
AMY-101 can induce a long-lasting anti-inflammatory effect[1].
AMY-101 (4 mg/kg bodyweight, subcutaneous injection. once per 24 hr for a total of 28 days) causes a significant and long-lasting reduction in PPD, an index that measures tissue destruction[1].
AMY-101 (Cp40, 1 mg/kg, sc, injection every 12 h, daily, 7 or 14 days) attenuates fibrosis and infiltration of inflammatory cells in UUO-induced renal fibrosis[3].

Animal Model:Fifteen adult male cynomolgus monkeys (Macaca fascicularis) (7-15 years old; 5.0-7.6 kg body weight)[1].
Dosage:0.1 mg/site; 50 μL of 2 mg/mL solution.
Administration:Injected locally. (Either three times per week or once a week for 6 weeks followed by a 6-week follow-up period without treatment.)
Result:Does not cause irritation in healthy gingiva.
Animal Model:UUO and sham-operated mice[3].
Dosage:1 mg/kg.
Administration:Subcutaneous injection every 12 h, daily, 7 or 14 days.
Result:1 mg/kg Cp40 had much less severe interstitial fibrosis than control peptide-injected mice.
Clinical Trial
性状

Solid

Formula

C83H117N23O18S2.xC2HF3O2

CAS 号

1789738-04-0

Sequence Shortening

YICV-{Trp(Me)}-QDW-{Sar}-AHRC-{N(Me)Ile}-NH2 (Disulfide bridge:Cys3-Cys13)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture and light

Powder-80°C2 years
-20°C1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性数据
In Vitro: 

H2O : 100 mg/mL(Need ultrasonic)

DMSO : 100 mg/mL(Need ultrasonic)