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ODN 2216
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:332437-00-0
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
50mg电议

产品介绍
ODN 2216 是一种TLR9(toll 样受体 9) 配体或激动剂。ODN 2216 诱导大量的IFN-αIFN-β。ODN 2216 通过 pDC (浆细胞样 DC) 诱导 IFN-α,并通过 DC (树突状细胞)产生IL-12 (p40)。ODN 2216 刺激外周血单核细胞 (PBMC) 产生 IFN-γ,这是间接的和由 IFN-α/β 介导的。ODN 2216 可以激活 NK 细胞,促进 IFN-γ 产生 TCR 触发的 CD4+T 细胞。
生物活性

ODN 2216 is aTLR9(toll-like receptor 9) ligand or agonist. ODN 2216 induces high amounts ofIFN-αandIFN-β. ODN 2216 induces IFN-α by pDC (plasmacytoid DC) andIL-12(p40)production by DC (dendritic cells). ODN 2216 stimulatesIFN-γproduction in peripheral blood mononuclear cells (PBMC), which is indirect and mediated by IFN-α/β. ODN 2216 can activate NK cells and promoteIFN-γproduction of TCR-triggeredCD4+T cells[1][2][3][4].

IC50& Target

TLR9

 

IL-12

 

体外研究
(In Vitro)

ODN 2216 (6 μg/mL, 9 days) drives Th1 development of naive CD4 T cells[1].
ODN 2216 (2 μM, 15 h) significantly decreased apoptosis of thymic DC[2].

Apoptosis Analysis[2]

Cell Line:Thymic DC, pDC
Concentration:2 μM
Incubation Time:15 h
Result:Significantly decreased apoptosis of thymic DC (23.1 ± 0.9%), and naturally induced apoptosis of thymic pDC was not decreased (72.8 ± 2.9%).
体内研究
(In Vivo)

ODN 2216 induces T-cell mediated antitumor immune response in murine vaccination models[3]

分子量

6432.00

性状

Solid

CAS 号

332437-00-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)