TCS PIM-1 1

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TCS PIM-1 1

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

491871-58-0

包装与价格：

包装	价格(元)
10 mM * 1 mL in DMSO	电议
10mg	电议
50mg	电议
100mg	电议
200mg	电议

产品名称

SC 204330

产品介绍

TCS PIM-1 1 (SC 204330) 是一种有效的，具有选择性和 ATP 竞争性的Pim-1激酶抑制剂，IC₅₀为 50 nM，对 Pim-2 和 MEK1/MEK2 表现出良好的选择性 (IC₅₀>20000 nM)。

生物活性

TCS PIM-1 1 (SC 204330) is a potent, selective and ATP-competitivePim-1kianse inhibitor with anIC₅₀of 50 nM, displays good selectivity over Pim-2 and MEK1/MEK2 (IC₅₀s >20000 nM)^[1].

IC₅₀& Target^[1]

PIM1

50 nM (IC₅₀)

体外研究
(In Vitro)

TCS PIM-1 1 (compound 1), a substituted pyridone scaffold, binds convincingly within the ATP-binding site of Pim-1 suggesting an ATP-competitive inhibitory mechanism. Preliminary data further suggests that TCS PIM-1 1 lacked in vitro inhibitory activity toward related serine/threonine kinases Pim-2 and MEK1/2. Hence, small molecules similar to TCS PIM-1 1 may serve as useful starting scaffolds for the development of other improved yet selective Pim-1 inhibitors. TCS PIM-1 1 serves both as a starting point for SAR chemical syntheses and was used for co-crystallization with Pim-1 protein^[1].

分子量

367.20

性状

Solid

Formula

C₁₈H₁₁BrN₂O₂

CAS 号

491871-58-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : 100 mg/mL(272.33 mM;Need ultrasonic)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	2.7233 mL	13.6166 mL	27.2331 mL
5 mM	0.5447 mL	2.7233 mL	5.4466 mL
10 mM	0.2723 mL	1.3617 mL	2.7233 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。

In Vivo:

1.
TCS PIM-1 1 is dissolved in 0.5% DMSO^[2].