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RET-IN-19
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
RET-IN-19图片
CAS NO:2484919-71-1
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
RET-IN-19 (compound 59) 是一种有效的RET抑制剂,对RET-wtRET V804MIC50值分别为 6.8 和 13.51 nM。RET-IN-19 具有抗癌活性。RET-IN-19 可用于非小细胞肺癌 (NSCLC) 研究。
生物活性

RET-IN-19 (compound 59) is a potentRETinhibitor, withIC50values of 6.8 and 13.51 nM againstRET-wtandRETV804M, respectively. RET-IN-19 shows anticancer activity. RET-IN-19 can be used for non-small cell lungcancer(NSCLC) research[1].

IC50& Target

EGFR

56.78 ± 4. μM (IC50)

Aurora A

0.242 ± 0. μM (IC50)

Aurora B

0.536 ± 45 μM (IC50)

MAP4K4

3.428 ± 0. μM (IC50)

体外研究
(In Vitro)

RET-IN-19 (compound 59) shows growth inhibition of LC-2/ad cells which RET-CCDC6 driven, with a GI50of 0.1067 ± 0.004 μM[1].
RET-IN-19 (3 μM) shows inhibition of LC-2/ad cells migration[1].
RET-IN-19 inhibits EGFR, Aurora A, Aurora B, Nek2, CSF-1R, MAP4K4, NIK, and RET, with IC50values of 56.78 ± 4.94, 0.242 ± 0.036, 0.536 ± 45.12, >200, 1.65 ± 0.235, 3.428 ± 0.150, >10, and 0.0068 ± 0.0003, respectively[1].

分子量

544.62

Formula

C28H28N6O4S

CAS 号

2484919-71-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.