MK2-IN-3 is a potent and selective inhibitor ofMAPKAP-K2 (MK-2), with anIC₅₀of 8.5 nM. MK2-IN-3 shows selectivity for MK-2 over MK-3, MK-5,ERK2,MNK1, p38a (IC₅₀s=0.21, 0.081, 3.44, 5.7, and >100 μM, respectively) and MSK1, MSK2,CDK2,JNK2, IKK2 (IC₅₀s>200 μM). MK2-IN-3 can reduce TNFα production in both U937 cells and in vivo^[1].

IC50: 8.5 nM (MK-2); 81 nM (MK-5); 210 nM (MK-3); 3.44 μM (ERK2); 5.7 μM (MNK1)^[1]

MK2-IN-3 (compound 16) inhibits MK-2 and TNFα production in U937 cells, with IC₅₀s of 8.5 nM and 4.4 μM, respectively^[1].

MK2-IN-3 (compound 16) (20 mg/kg; a single p.o. before LPS challenge) inhibits 20% TNFα production in rat LPS (rLPS) model^[1].

340.38

Solid

C₂₁H₁₆N₄O

724711-21-1

Room temperature in continental US; may vary elsewhere.

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

DMSO : 62.5 mg/mL(183.62 mM;Need ultrasonic)

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (protect from light)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。