| CAS NO: | 1186648-22-5 |
| 包装 | 价格(元) |
| 1mg | 电议 |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| 50mg | 电议 |
| 生物活性 | MK2-IN-3 hydrate (compound 16) is an orally active, selective, and ATP-competitiveMAPKAP-K2 (MK-2)inhibitor with anIC50of 0.85 nM.MK2-IN-3 hydrate is exceptional selectivity against MK-3 (IC50=0.21 μM), MK-5 (IC50=0.081 μM),ERK2(IC50=3.44 μM), MNK1(IC50=5.7 μM) as well asCDK2,JNK2, IKK2, MSK1, and MSK2[1]. | |||||||||
| IC50& Target | IC50: 0.85 nM (MK-2), 0.21 μM (MK-3), 0.081 μM (MK-5), 3.44 μM (ERK2), 5.7 μM (MNK1)[1] | |||||||||
| 体外研究 (In Vitro) | MK2-IN-3 hydrate suppresses TNFα production in U397 cells with an IC50of 4.4 μM[1]. | |||||||||
| 分子量 | 358.39 | |||||||||
| 性状 | Solid | |||||||||
| Formula | C21H18N4O2 | |||||||||
| CAS 号 | 1186648-22-5 | |||||||||
| 运输条件 | Room temperature in continental US; may vary elsewhere. | |||||||||
| 储存方式 |
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