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Necrosulfonamide-d4
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Necrosulfonamide-d4图片
CAS NO:1795144-22-7
包装与价格:
包装价格(元)
1mg电议
10mg电议

产品介绍
Necrosulfonamide-d4 是 Necrosulfonamide 的氘代物。Necrosulfonamide,一种necroptosis抑制剂,通过选择性靶向(MLKL)。Necrosulfonamide 阻止 MLKL-RIP1-RIP3 坏死小体复合体与其下游效应子相互作用。MLKL 是诱导坏死过程中 RIP3 的重要底物。
生物活性

Necrosulfonamide-d4 is the deuterium labeled Necrosulfonamide. Necrosulfonamide is anecroptosisinhibitor acting by selectively targeting themixed lineage kinasedomain-like protein(MLKL). Necrosulfonamide prevents MLKL-RIP1-RIP3 necrosome complex from interacting with its downstream effectors. MLKL is a critical substrate of RIP3 during the induction of necrosis[1].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

分子量

465.50

Formula

C18H11D4N5O6S2

CAS 号

1795144-22-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.