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PROTAC BRAF-V600E degrader-1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PROTAC BRAF-V600E degrader-1图片
CAS NO:2417296-84-3
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
50mg电议

产品介绍
PROTAC BRAF-V600E degrader-1 是一种有效的PROTAC BRAF-V600E降解剂,对 BRAF 和 BRAF-V600E 的Kd分别为 2.4 nM 和 2 nM。PROTAC BRAF-V600E degrader-1 通过泛素-蛋白酶体系统 (UPS) 降解 BRAF-V600E。PROTAC BRAF-V600E degrader-1 可抑制黑色素瘤细胞的生长。
生物活性

PROTACBRAF-V600E degrader-1 is a potentPROTACBRAF-V600Edegrader withKdvalue of 2.4 nM and 2 nM forBRAFand BRAF-V600E, respectively.PROTACBRAF-V600E degrader-1 degrades BRAF-V600E via the ubiquitin-proteasome system (UPS).PROTACBRAF-V600E degrader-1 can inhibit melanoma cell growth[1].

IC50& Target[1]

BRAF-V600E

2 nM (Kd)

Braf

2.4 nM (Kd)

体外研究
(In Vitro)

PROTAC BRAF-V600E degrader-1 (compound 23) (1 nM-10 μM; 72 h) inhibits the cell viability of A375 and HT-29[1].
PROTAC BRAF-V600E degrader-1 (1-1000 nM; 16 h or 0-24 h) inhibits p-ERK and BRAF-V600E protein in A375 cells[1].

Cell Viability Assay[1]

Cell Line:A375 and HT-29
Concentration:1 nM-10 μM
Incubation Time:72 h
Result:Inhibited the cell viability of A375 and HT-29 with IC50s of 46.5 nM and 51 nM.

Western Blot Analysis[1]

Cell Line:A375
Concentration:1, 4, 12, 37, 111, 333 and 1000 nM
Incubation Time:16 h or 0-24 h
Result:Induced the reduction in the phosphorylation of ERK.
Inhibited p-ERK and BRAF-V600E in a dose- and time-dependent manner.
分子量

1001.07

性状

Solid

Formula

C48H54F2N10O10S

CAS 号

2417296-84-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder-20°C3 years
4°C2 years
In solvent-80°C6 months
-20°C1 month