Iclepertin (BI-425809) is a potent, selective and orally activeglycine transporter 1 (GlyT1)inhibitor. Iclepertin is inactive againstGlyT2. Iclepertin can be used for Alzheimer disease and schizophrenia research^[1].

Iclepertin inhibits GlyT1 with the IC₅₀values of 5.2 nM in rat primary neurons and 5.0 nM in human SK-N-MC cells^[1].

Single oral administration of Iclepertin induced a dose-dependent increase of glycine cerebrospinal fluid (CSF) levels. Oral administration of Iclepertin in rats induced a dose‐dependent increase of glycine CSF levels from 30% (0.2 mg/kg, not significant) to 78% (2 mg/kg), relative to vehicle^[1].

512.42

Solid

C₂₀H₁₈F₆N₂O₅S

1421936-85-7

Room temperature in continental US; may vary elsewhere.

DMSO : 11.36 mg/mL(22.17 mM;ultrasonic and warming and heat to 60℃)

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。