AR-C141990 hydrochloride is a potentlactate transporters (monocarboxylate transporters; MCTs)inhibitor withpK_ivalues of 7.6, 6.6 for MCT-1 and MCT-2, respectively^[1]. AR-C141990 hydrochloride has immunosuppressive properties and inhibits graft versus host response^[2].

pKi: 7.6 (MCT-1) and 6.6 (MCT-2)^[1]

AR-C141990 hydrochloride has no significant activity against MCT-3 (pIC₅₀<5) or MCT-4 (pIC₅₀<5)^[1].
AR-C141990 hydrochloride inhibits the uptake of [³H]HOCPCA in oocytes expressing MCT1 or 2 in a concentration-dependent manner with IC₅₀s of 0.21 μM and 2.32 μM, respectively^[2].

AR-C141990 hydrochloride (10 mg/kg; SC) with a parallel decline in plasma concentrations with a half-life around 20 minutes in male NMRI mice (18-22 g)^[2].
Application of the corresponding plasma concentrations of AR-C141990 hydrochloride (0.3-90 mg/kg) results in a concentration-dependent decrease in the B/P of HOCPCA with an EC₅₀of 860 ng/ml^[2].
AR-C141990 (100 mg/kg; s.c.) has a moderate prolongation of graft survival for 40 days in PVG rats that received DA cardiac transplants^[1].

529.05

C₂₆H₂₉ClN₄O₄S

2250019-94-2

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.