Tenapanor hydrochloride

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1234365-97-9

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品名称

AZD1722 hydrochloride
RDX5791 hydrochloride

产品介绍

Tenapanor (AZD1722) hydrochloride 是一种有效且具有口服活性的钠/氢交换异构体 3 (NHE3) (sodium/hydrogen exchanger isoform 3 (NHE3)) 抑制剂。Tenapanor hydrochloride 主要通过减少被动细胞旁磷酸盐通量来减少肠道对磷酸盐的吸收。Tenapanor hydrochloride 具有研究高磷血症的潜力。

生物活性

Tenapanor (AZD1722) hydrochloride is a potent and orally activesodium/hydrogen exchanger isoform 3 (NHE3)inhibitor. Tenapanor hydrochloride reduces intestinal phosphate absorption predominantly through reduction of passive paracellular phosphate flux. Tenapanor hydrochloride has the potential for the research of hyperphosphatemia^[1]^[2].

体内研究
(In Vivo)

Tenapanor hydrochloride (0.15, 0.5 mg/kg; p.o.) reduces passive paracellular phosphate absorption in rats^[1].
Tenapanor hydrochloride (0.15 mg/kg; p.o.; twice-daily for 11 consecutive days) increases the reduction in urinary phosphorus excretion in rats^[2].

Animal Model:	Rats (intestinal loop model)^[1]
Dosage:	0.15, 0.5 mg/kg
Administration:	P.o.
Result:	Reduced passive paracellular phosphate absorption by reduced urinary phosphate and sodium excretion after the high-phosphate meal and increased sodium and phosphate delivery to the cecum.

Animal Model:	8 weeks, 250 g male Sprague–Dawley rats^[2]
Dosage:	0.15 mg/kg in combination with sevelamer (0%, 0.75%, 1.5%, and 3% (wt/wt))
Administration:	Oral gavage; twice-daily for 11 consecutive days
Result:	Significantly augmented the reduction in urinary phosphorus excretion.

Clinical Trial

分子量

1217.97

Formula

C₅₀H₆₈Cl₆N₈O₁₀S₂

CAS 号

1234365-97-9

中文名称

盐酸替那帕诺

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.