Finasteride acetate

立即咨询

Finasteride acetate

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

222989-99-3

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品名称

醋酸非那雄胺
MK-906 acetate

产品介绍

Finasteride (MK-906) acetate 是一种有效的竞争性 5α-还原酶 (5α-reductase) 抑制剂，对 II 型 5α-还原酶的IC₅₀值为 4.2 nM。Finasteride acetate 对 II 型 5α-还原酶的亲和力比对 I 型酶高约 100 倍。Finasteride acetate 可用于研究前列腺增生 (BPH) 和雄激素性脱发。

生物活性

Finasteride (MK-906) acetate is a potent and competitive5α-reductaseinhibitor, with anIC₅₀of 4.2 nM for type II 5α-reductase. Finasteride acetate has approximately a 100-fold greater affinity for type II 5α-reductase enzyme than for the type I enzyme. Finasteride acetate can be used for the research of benign prostatic hyperplasia (BPH) and androgenic alopecia^[1]^[2]^[3].

IC₅₀& Target

IC50: 4.2 nM (type II 5α-reductase)^[1]

体外研究
(In Vitro)

Finasteride (10 μM; 6-24 h) induces the expression of HO-1 and Nrf2 proteins in PC-3 cells^[2].
Finasteride decreases the conversion of [³H]testosterone (T) to [³H]dihydrotestosterone (DHT) inP. crustosum^[1].

Cell Viability Assay^[2]

Cell Line:	PC-3, DU-145, and LNCaP cells
Concentration:	10 μM
Incubation Time:	6, 12, 24 h
Result:	Increased the expression of HO-1 protein in a time-dependent manner in PC-3 cells. Induced the expression of Nrf2 protein in DU-145 and PC-3 cells, but not in LNCaP cells.

体内研究
(In Vivo)

Finasteride (0.1-0.5 mg/kg; p.o. once daily for 16 weeks) reduces prostatic size in dogs with BPH without adversely affecting semen quality or serum testosterone concentration^[3].

Animal Model:	Male dogs with spontaneous BPH (2.7-11 years old; 10.3-49 kg)^[3]
Dosage:	0.1-0.5 mg/kg
Administration:	P.o. once daily for 16 weeks
Result:	Decreased prostatic diameter (20%), prostatic volume (43%), and serum DHT concentration (58%). Decreased semen volume but did not adversely effect on semen quality or serum testosterone concentration. No adverse effects on dogs.

Clinical Trial

分子量

432.60

Formula

C₂₅H₄₀N₂O₄

CAS 号

222989-99-3

中文名称

醋酸非那雄胺；醋酸非那斯特萊

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.