Entacapone-d10 is the deuterium labeled Entacapone. Entacapone is a potent, reversible, peripherally acting and orally activecatechol-O-methyltransferase (COMT)inhibitor. Entacapone inhibitsCOMTfrom rat brain, erythrocytes and liver withIC₅₀values of 10 nM, 20 nM, and 160 nM, respectively. Entacapone is selective forCOMTover other catecholamine metabolizing enzymes, includingMAO-A,MAO-B, phenolsulphotransferase M (PST-M) and PST-P (IC₅₀s>50 μM). Entacapone can be used for the research of Parkinson's disease^[1]. Entacapone serves as a inhibitor ofFTO demethylationwith anIC₅₀of 3.5 μM, can be used for the research of metabolic disorders^[2].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

315.35

Solid

C₁₄H₅D₁₀N₃O₅

1185241-19-3

恩他卡朋 d10

Room temperature in continental US; may vary elsewhere.

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)