Isavuconazonium (sulfate) (BAL8557-002) 是活性三唑 Isavuconazole 的前药，是一种口服活性抗真菌剂。
| Cas No. | 946075-13-4 |
| 别名 | 艾沙康唑硫酸盐,BAL8557-002 |
| Canonical SMILES | O=C(CNC)OCC1=C(N(C)C(OC(C)[N+]2=CN(C[C@@](C3=CC(F)=CC=C3F)(O)[C@@H](C)C4=NC(C5=CC=C(C#N)C=C5)=CS4)N=C2)=O)N=CC=C1.O=S([O-])(O)=O |
| 分子式 | C35H35F2N8O5S•HO4S |
| 分子量 | 814.8 |
| 溶解度 | DMSO: 20 mg/ml,DMSO:PBS (pH 7.2)(1:5): 0.16 mg/ml,Ethanol: 10 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Isavuconazonium is a water-soluble prodrug form of the azole antifungal isavuconazole (ISA). Oral administration of isavuconazonium increases survival in rat models of azole-susceptible and -resistant A. fumigatus infection when administered at doses ranging from 0.25 to 512 mg/kg per day (ISA-equivalent = 0.12-245.8 mg/kg per day). Isavuconazonium reduces fungal burden and organism-mediated pulmonary injury and increases survival in a rabbit model of experimental invasive pulmonary aspergillosis when administered at ISA-equivalent doses ranging from 40 to 60 mg/kg. |
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