细胞松弛素 A 是一种细胞渗透性真菌毒素，是细胞松弛素 B 的氧化衍生物。
| Cas No. | 14110-64-6 |
| 别名 | 细胞松弛素A |
| Canonical SMILES | O=C1/C=C/[C@H](O)CCC[C@@H](C)C/C=C/[C@](C(C([C@@H](C)[C@@]2([H])[C@H](CC3=CC=CC=C3)NC4=O)=C)=O)([H])[C@@]24O1 |
| 分子式 | C29H35NO5 |
| 分子量 | 477.6 |
| 溶解度 | DMF: 30 mg/ml,DMF:PBS (pH 7.2) (1:20): 0.05 mg/ml,DMSO: 20 mg/ml,Ethanol: 20 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | The cytochalasins are cell-permeable fungal metabolites which inhibit actin polymerization. This interferes with such diverse processes as cell movement, growth, phagocytosis, degranulation, and secretion. Cytochalasin A is an oxidized analog of cytochalasin B which uniquely inhibits HIV-1 protease (IC50 = 3 μM). Cytochalasins A and B differ from other cytochalasins in being able to rapidly and reversibly inhibit glucose transport by competitively binding glucose transporters (Ki = 4.0 and 0.6 μM, respectively). Cytochalasin A also induces the phosphorylation of the tyrosine phosphatase PTP3 of Dictyostelium, activating STATc. |
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